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目的研究市场两种习用土荆皮代用药材的体外抗真菌活性,为土荆皮的习用药材(水翁皮与余甘子皮)的药理应用提供依据。方法采用药基琼脂稀释法,研究水翁皮与余甘子皮的提取物对11株浅表性皮肤癣菌的最小抑菌浓度(MIC)和最低杀菌浓度(MFC)。结果土荆皮的提取物对武汉须毛癣菌、武汉近平滑癣菌的MIC和MFC3.13μl/ml,对其余9株皮肤癣菌的MIC和MFC6.25μl/ml,水翁皮与余甘子皮的提取物对试验11株皮肤癣菌的MIC和MFC>50μl/ml,达克宁的MIC和MFC<0.78μl/ml。结论土荆皮的两种习用药材水翁皮与余甘子皮体外对11株皮肤癣菌未显示出抗真菌活性。
OBJECTIVE To study the antifungal activities of two medicinal materials in vitro on the market, and to provide the basis for the pharmacological application of the medicinal materials (water wampee and emblica hirsutum). Methods The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MFC) of 11 strains of superficial dermatophytes were studied by agar dilution method. Results The extracts of Rhizoma et Radix Bunge, Rhizoctonia solani, MIC and MFC of Wuhan Trichophyton mentagrophytes, and the number of MICs and MFCs of Rhizoctonia solani were 3.13μl / ml and 6.25μl / ml of MIC and MFC of the other 9 strains of Trichophyton mentagrophytes, Skin extracts were tested against 11 dermatophytes for MIC and MFC> 50 μl / ml, merkin MIC and MFC <0.78 μl / ml. Conclusion There were no antifungal activities on 11 strains of dermatophytes in two indigenous medicinal materials, Shui Ona and Phyllanthus emblica, in vitro.