作者报告4例年轻的黑人妇女,最初均诊断为系统性硬化,有手部皮肤发硬、手肿、手指硬化、雷诺氏征、关节痛、淋巴结肿大等症状. 3例有吞咽困难, 2例消瘦及肌无力,另1例有颊部红斑.化验室检查有血沉加快、免疫球蛋白增多、肌酸磷酸激酶值升高,抗核因子滴度较高等现象,3例有轻度的和系统性红斑狼疮或皮肌炎症状相重叠的征象.作者对上述病例的正常皮肤作了活体组织冰冻切片,以IgG等抗血清作直接荧光标记,显示在表皮细胞核上有斑点状荧光.由于混合性结缔组织病具有ENA抗体及表皮细胞核上有斑点状IgG抗体 The authors reported that four young black women, initially diagnosed as systemic sclerosis, had hand-skin sclerosis, hand swelling, finger sclerosis, Raynaud’s syndrome, joint pain, swollen lymph nodes and other symptoms .3 had dysphagia, 2 Cases of weight loss and muscle weakness, another case of cheek erythema. Laboratory tests have ESR, increased immunoglobulin, creatine phosphokinase value increased, anti-nuclear factor titer higher phenomenon, 3 patients with mild and Systemic lupus erythematosus or dermatomyositis symptoms superimposed signs of the above cases of normal skin made of frozen sections of living tissue to IgG and other antisera for direct fluorescent labeling showed that the epidermal nuclei have speckled fluorescence due to mixing Sexual connective tissue disease with ENA antibodies and epidermal cell nuclei have spotted IgG antibodies