论文部分内容阅读
采用改进的pH梯度法制备吲哚美辛(1)醇质体,所得制品平均粒径为197.84 nm,包封率为(88.25±1.04)%。用Franz扩散池测试其对大鼠离体皮肤的渗透特性,并与1脂质体和搽剂对比。结果表明,1醇质体、1脂质体和搽剂的体外渗透速率分别为102.99、27.45和73.06 g·cm-2·h-1,给药4 h后皮内滞留量分别为96.54、78.52和36.62 g/cm2。用乙酸致小鼠扭体和甲醛致小鼠左前足疼痛试验考察制品的镇痛作用,用卡拉胶致小鼠左后足肿胀和二甲苯致小鼠耳肿胀考察其抗炎作用。结果表明,所制备的1醇质体抑制小鼠疼痛与炎症的效果均优于其脂质体和市售搽剂。
The indomethacin (1) ethosome was prepared by a modified pH gradient method. The average particle diameter of the obtained product was 197.84 nm, and the entrapment efficiency was (88.25 ± 1.04)%. The Franz diffusion cells were used to test their permeability to isolated rat skin and compared to 1 liposomes and liniment. The results showed that the in vitro permeation rates of 1 alcohol, 1 liposome and liniment were 102.99,27.45 and 73.06 g · cm-2 · h-1, respectively, and the intradermal retention was 96.54 and 78.52 And 36.62 g / cm2. Acetic acid induced writhing in mice and formaldehyde induced pain in the left foreleg of mice. The anti-inflammatory effects of the products were evaluated by carrageenan-induced swelling in the left hind paw and xylene-induced ear swelling in mice. The results showed that the preparation of an alcohol suppressive effect on mice with pain and inflammation are superior to their liposomes and the commercially available liniment.