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目的探讨普罗帕酮联合美托洛尔治疗先天性心脏病诱发小儿心律失常的疗效。方法选取简阳市人民医院2011年8月—2015年2月确诊并收治的62例先天性心脏病诱发心律失常患儿,随机分为研究组和对照组,各31例。对照组患儿应用普罗帕酮治疗,研究组在对照组基础上给予美托洛尔治疗。比较两组临床疗效、治疗前后房性期前收缩、室性期前收缩、短阵房性心动过速、短阵室性心动过速24h发作次数和不良反应发生情况。结果研究组总有效率高于对照组(P<0.05)。治疗前两组患儿房性期前收缩、室性期前收缩、短阵房性心动过速及短阵室性心动过速24h发作次数比较,差异无统计学意义(P>0.05);治疗后研究组患儿房性期前收缩、室性期前收缩、短阵房性心动过速及短阵室性心动过速24h发作次数少于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论普罗帕酮联合美托洛尔可显著改善患儿心律失常症状,降低心律失常的发作频率,且安全性好。
Objective To investigate the efficacy of propafenone combined with metoprolol in the treatment of children with congenital heart disease induced by arrhythmia. Methods 62 cases of congenital heart disease induced arrhythmia diagnosed and treated in Jianyang People’s Hospital from August 2011 to February 2015 were randomly divided into study group and control group, with 31 cases in each group. The control group of children with propafenone treatment, the study group on the basis of the control group metoprolol treatment. The clinical curative effect was compared between the two groups before and after treatment atrial contraction, ventricular contraction, short atrial tachycardia, shortness of ventricular tachycardia onset of 24h and adverse reactions occurred. Results The total effective rate of the study group was higher than that of the control group (P <0.05). Two groups of children atrial contraction before treatment, ventricular contractions, Comparative paroxysmal atrial tachycardia and paroxysmal ventricular tachycardia episodes 24h, no significant difference (P> 0.05); Treatment after the study group of children before atrial contraction, ventricular contractions, paroxysmal atrial tachycardia and ventricular tachycardia 24h paroxysmal episodes than the control group, the difference was statistically significant (P <0.05) . The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion Propafenone combined with metoprolol can significantly improve the symptoms of arrhythmia in children and reduce the frequency of arrhythmia attack, and the safety is good.