1引言在肾功能不全时,由于水溶性药物和药物的代谢产物清除率降低,如按常规用药会导致血药浓度过高,必须根据药物清除率下降的程度进行剂量个体化处理,尤其对于治疗窗较窄的药物更为重要。在肾功能不全时,药物清除率下降了多少?是否需要进行剂量调整,给药剂量和给药间隔要作哪 1 Introduction In renal insufficiency, due to reduced clearance of metabolites of water-soluble drugs and drugs, such as conventional drug use can lead to high plasma concentrations, dose-specific treatment must be based on the degree of decline in drug clearance, especially for treatment The narrower window is even more important. In renal insufficiency, drug clearance decreased by how much? Whether the need for dose adjustment, dosage and administration interval to be made