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M-Nif对离体豚鼠左心房的钙拮抗作用PD_2~′=7.05较Nif PD_2~′=7.19弱,抑制心肌的IC_(50)=7.5×10~(-8)M亦较Nif IC_(50)=2.9×10~(-6)M弱2.6倍。在离体猪冠脉条实验中M-Nif PD_2~′=7.06,Nif PD_2~′=6.88,前者稍强,前者抑制血管的作用IC_(50)=6.166×10~(-7)M亦强于后者IC_(50)=7.02×10~(-7)M 114倍,Nif扩张血管作用较抑制心肌作用强10倍,提示M-Nif扩张血管与抑制心肌的宽度更大,对治疗心力衰竭、降压将更有利。
The calcium antagonistic effect of M-Nif on the left atrium of isolated guinea pigs was also weaker than that of Nif PD_2 ~ = 7.19, and the IC 50 of 7.5 × 10 -8 M ~ ) = 2.9 × 10 ~ (-6) M is 2.6 times weaker. M-Nif PD_2 ~ ’= 7.06 and Nif PD_2 ~’ = 6.88 in isolated porcine coronary arteries, the former slightly stronger and the former inhibited blood vessel function IC 50 = 6.166 × 10 -7 M In the latter IC50 = 7.02 × 10 ~ (-7) M 114 times, the effect of Nif dilation of blood vessels is 10 times stronger than that of the inhibition of cardiac muscle, suggesting that M-Nif dilates blood vessels and inhibits the width of myocardial more, , Blood pressure will be more favorable.