论文部分内容阅读
了解支气管淋巴结结核患儿炎性介质水平变化。方法 应用ELISA法检测47例结核(TB)抗体阳性和42 例结核菌素(PPD)阳性的支气管淋巴结结核患儿血清炎性介质(IL-2、IL-8 和TNF-α)含量。结果 TB抗体阳性组上述三项指标分别为416.56±66.38ng/L、71.82±23.24ng/L和584.32±213.24ng/L,其含量均高于同龄对照组,P< 0.001。PPD阳性组上述三项指标分别为 548.24±71.26ng/L、97.67±24.38ng/L 和745.47±208.38ng/L,亦高于正常对照组(P< 0.001)和TB抗体阳性组(P< 0.001)。结论 1.TB菌进入机体后的急性感染期,炎性介质可迅速增长。导致肺门支气管淋巴结组织细胞浸润坏死,造成肺部损伤。2.两组TBIL-8 和TNF-α呈正相关,IL-8 和TNF-α,激发了抗菌性炎症,在结核浸润期可起到诱导作用。故对本病的分期、治疗和预后判断有着重要意义
To understand the changes of inflammatory mediators in children with bronchial lymphadenitis. Methods Serum inflammatory mediators (IL-2, IL-8 and TNF-α) were detected in 47 children with tuberculosis (TB) and 42 with tuberculin (PPD) positive bronchial tuberculosis by ELISA. Results TB antibody positive group of the above three indicators were 416.56 ± 66.38ng / L, 71.82 ± 23.24ng / L and 584.32 ± 213.24ng / L, the content were higher than the same age control group, P <0.001. The above three indexes of PPD positive group were 548.24 ± 71.26ng / L, 97.67 ± 24.38ng / L and 745.47 ± 208.38ng / L respectively, which were also higher than those of normal control group and TB antibody positive group (P <0.001) ). Conclusion 1.TB bacteria into the body after acute infection, inflammatory mediators can rapidly increase. Leading to hilar bronchial lymph node tissue infiltration and necrosis, resulting in lung damage. There was a positive correlation between TBIL-8 and TNF-α, IL-8 and TNF-α in both groups, which stimulated anti-bacterial inflammation and could induce tuberculosis infiltration. Therefore, the stage of the disease, treatment and prognosis of great significance