长期暴露于高血糖环境中,会影响胰岛素基因的转录或表达,导致不可逆的β细胞功能损害和细胞凋亡[1]。短时间高血糖只影响β细胞胰岛素的胞吐功能或胰岛素储存,所导致的β细胞功能受损是暂时的、可逆的[2]。胰岛β细胞功能缺陷在早期主要表现为胰岛素分泌第一时相消失,在静脉输 Prolonged exposure to hyperglycemic conditions can affect the transcription or expression of the insulin gene, leading to irreversible beta-cell dysfunction and apoptosis [1]. Short-term hyperglycemia affects only β-cell insulin exocytosis or insulin storage, resulting in β-cell impairment is transient and reversible [2]. Pancreatic islet β-cell function defects in the early performance of insulin secretion disappeared the first time, in the intravenous