以前的研究发现,细胞的Poly(C)结合蛋白2(PCBP2)可以下调水疱性口炎病毒的基因表达。作者的研究表明,水疱性口炎病毒感染可以诱导含细胞RNA结合蛋白的细胞质中颗粒状结构的形成,这些蛋白包括PCBP2、T细胞限制性细胞内抗原1(TIA1)以及TIA1相关性蛋白(TIAR)。通过小干扰RNA(siRNAs)而使TIA1缺失,而非TIAR缺失,而使水疱性口炎病毒的生长和基因表达增强。该病毒诱导的颗粒似乎与经过热休克或氧化应力触发的 Previous studies have found that the cellular poly (C) binding protein 2 (PCBP2) can down-regulate the gene expression of the vesicular stomatitis virus. Authors’ studies have shown that vesicular stomatitis virus infection can induce the formation of granular structures in the cytoplasm of cell-containing RNA-binding proteins, including PCBP2, T cell-restricted intracellular antigen 1 (TIA1), and TIA1-associated protein (TIAR ). The growth and gene expression of vesicular stomatitis virus is enhanced by the deletion of TIA1 by small interfering RNAs (siRNAs) rather than TIAR deletion. The virus-induced particles appear to be triggered by heat shock or oxidative stress