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目的探讨１４Ｃ尿素呼吸试验和血清ＨｐＩｇＧ对于抗Ｈｐ感染疗效监测的应用价值．方法确诊Ｈｐ感染４０例，改良三联疗法３０例，单用铋剂１０例，疗程２周．于治疗前及治疗结束后４，１２，２４，４８周做１４Ｃ尿素呼吸试验、ＥＬＩＳＡ法血清ＨｐＩｇＧ抗体测定、胃粘膜活检标本组织学及细菌培养，监测Ｈｐ感染状态．结果经抗Ｈｐ治疗后４０例中有２５例Ｈｐ根除且持续阴性，１０例未根除者持续阳性，５例根除后随访中又复发．呼吸试验能准确反映Ｈｐ根除及根除后复发或治疗无效，与组织学或培养比较其敏感性和特异性分别为１００％和９７９％．血清ＨｐＩｇＧ抗体在Ｈｐ根除后即有明显下降，随时间延长下降幅度逐渐增大；Ｈｐ未根除者随访中无明显变化；在Ｈｐ根除后复发者，已下降的抗体又达到或超过治疗前水平．结论１４Ｃ尿素呼吸试验和血清ＨｐＩｇＧ抗体测定准确性高，是简便、安全的非侵入性抗Ｈｐ感染疗效监测方法．
Objective To investigate the value of 14 C urea breath test and serum Hp IgG in monitoring the curative effect of anti-Hp infection. Methods Hp infection was diagnosed in 40 cases, 30 cases improved triple therapy, bismuth alone 10 cases, treatment for 2 weeks. Before treatment and after treatment, 14 C urea breath test was performed at 4, 12, 24 and 48 weeks after the treatment, Hp IgG was detected by ELISA, histology and bacterial culture of gastric mucosa biopsy, and the status of Hp infection was monitored. Results After anti-Hp treatment, 25 cases of Hp eradication and persistent negative in 40 cases, 10 cases of non-eradication continued positive, 5 cases of recurrence after eradication and follow-up. Breathing test can accurately reflect the eradication of Hp and eradication or relapse after treatment ineffective, compared with histology or culture its sensitivity and specificity were 100% and 97 9%. Serum Hp IgG antibodies significantly decreased after Hp eradication, decreased with time gradually increased; Hp non-eradication follow-up no significant change in the recurrence of Hp eradication, antibodies have been reduced or exceeded before treatment Level. Conclusion 14C urea breath test and serum Hp IgG antibodies with high accuracy, is simple, safe and non-invasive anti-Hp infection efficacy monitoring method.