论文部分内容阅读
探讨器官功能衰竭（ＯＦ）患者血浆血管活性肠肽（ＶＩＰ）水平的变化及其临床意义。对３０例ＯＦ患儿和３０例对照组的血浆ＶＩＰ水平进行了放免测定，并对ＯＦ组中的１４例患者（包括死亡６例和痊愈８例）血浆ＶＩＰ水平进行了动态观察。结果表明：ＯＦ组血浆ＶＩＰ水平明显高于对照组（３４．３９±１０．３４ｎｇ／Ｌ比１１．９０±９．８４ｎｇ／Ｌ，Ｐ＜０．００１）；随病情好转，８例痊愈者４８～７２小时血浆ＶＩＰ水平呈显著升高（Ｐ＜０．０５），并随ＯＦ的控制ＶＩＰ处于较高水平，且持续数日，而后随疾病康复渐至正常。而６例死亡者临终时ＶＩＰ多呈现低值。表明ＶＩＰ升高是一种免疫反应；ＶＩＰ参与了ＯＦ的发病过程。提示：血浆ＶＩＰ水平可作为ＯＦ的一种预警指标；ＶＩＰ作为一种内源性调节物质对损伤脏器有保护作用，若能增加体内ＶＩＰ含量，可能为ＯＦ治疗提供一条新的途径
To investigate the changes of plasma vasoactive intestinal peptide (VIP) in patients with organ failure (OF) and its clinical significance. Plasma VIP levels were measured in 30 children with OF and in 30 controls, and plasma levels of VIP in 14 patients (including 6 dead and 8 cured) in OF group were observed. The results showed that the plasma VIP level in OF group was significantly higher than that in control group (34.39 ± 10.34ng / L vs 11.90 ± 9.84ng / L, P <0.001) Plasma VIP level was significantly increased at ~72 hours (P <0.05), and was at a high level with the control of VIP, and lasted for several days, then recovered to normal with disease recovery. While the death of 6 patients showed a low value of VIP at the end of the death. That VIP is an immune response; VIP involved in the pathogenesis of OF. Tip: Plasma VIP level can be used as an indicator of OF; VIP as an endogenous regulatory substance has a protective effect on visceral organs, if increased in vivo VIP content may provide a new way for OF treatment