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前言:舒洛地特(SDX)是葡糖胺葡聚糖(GAG)类物质。这类物质具有粘性,因此也被称为粘多糖。GAG是一大类发现于哺乳动物组织中的带负电荷的多聚碳水化合物,在很多生命活动中都具有重要的作用。其能够调控一系列蛋白在生理和病理情况下的活动,包括趋化因子、细胞因子、生长因子、酶、构型素和粘附分子等[1]。GAGs还能够通过介导细胞-细胞或细胞-间质的相互作用,在多细胞器官的发育和维持正常功能方面发挥着不可或缺的作用[2]。
Foreword: Schuluutide (SDX) is a glucosamine glucan (GAG) substance. These substances are sticky and therefore also known as mucopolysaccharides. GAG is a large class of negatively charged polycarbohydrate found in mammalian tissues and plays an important role in many life activities. It regulates the activities of a range of proteins under physiological and pathological conditions, including chemokines, cytokines, growth factors, enzymes, conformations, and adhesion molecules [1]. GAGs also play an integral role in the development and maintenance of normal functions of multicellular organs by mediating cell-cell or cell-interstitial interactions [2].