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扶绥县是全国肝癌高发区之一。1978～82年年均标化死亡率为56.53/10万。其中一些肝大、肝病患者和肝癌高发家庭的肝癌发病率更高为331.3/10万。HBsAg携带者为649.35/10万。因此,我们在1976年底开始对上述高危险人群进行药物预防。经过三年的随访观察,发现左旋咪唑有一定的预防效果。于1981年6月开始,在该县八个高发大队(年均死亡率为92.25～103.54/10万)重新设计,再次进行实验研究。现经三年的随访复查,说明左旋咪唑确有降低肝癌发病率的作用。
Fusui County is one of the high-risk areas for liver cancer in the country. The average annual standardized mortality rate for the period 1978-82 was 56.53/100,000. Some of these patients with hepatomegaly, liver disease, and high incidence of liver cancer had a higher prevalence of 331.3/10 million. The HBsAg carriers are 649.35/100000. Therefore, we started drug prevention for these high-risk groups at the end of 1976. After three years of follow-up observation, it was found that levamisole has a certain preventive effect. Beginning in June 1981, eight high-rising brigades (average annual mortality rate of 92.25 to 103.54/100,000) were redesigned and the experimental study was conducted again. Follow-up review after three years shows that levamisole does reduce the incidence of liver cancer.