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目的:评价妊娠期糖尿病患者血清胆红素与胰岛素抵抗和妊娠结局的关系.方法:自2020年7月至2021年8月期间抽取在本院进行产检的孕妇120例列为观察对象,回顾所有孕妇的相关资料,将其按是否为妊娠期糖尿病患者作为分组依据,将120例孕妇分为两组,即妊娠期糖尿病者(52例)与非妊娠期糖尿病者(68例),两组研究对象均开展相关检查,即总胆红素、直接胆红素、空腹胰岛素、空腹血糖水平,对两组研究对象的胰岛素抵抗指标进行计算,对比两组妊娠结局,同时评价妊娠期糖尿病患者血清胆红素与胰岛素抵抗、妊娠结局之间的关系.结果:“,”Objective:To evaluate the relationship between serum bilirubin and insulin resistance and pregnancy outcome in gestational diabetes mellitus.Methods:from July 2020 to August 2021,120 pregnant women were selected as the observation subjects.All the pregnant women were reviewed.According to whether they were pregnant women with diabetes mellitus,120 pregnant women were divided into two groups,that is,gestational diabetes mellitus(52 cases)and non gestational diabetes mellitus(68 cases).Two groups of subjects were carried out relevant checks,that is,total bilirubin,direct bilirubin,fasting insulin,fasting blood glucose levels,the two groups of subjects insulin resistance indicators were calculated, compared two groups of pregnancy outcomes,and evaluate the relationship between serum bilirubin and insulin resistance,pregnancy outcome in patients with gestational diabetes mellitus.Results:the levels of total bilirubin and direct bilirubin in the two groups decreased in the early,middle and late pregnancy(P ＜ 0.05).There was no difference in insulin resistance index between early pregnancy,middle stage and late stage in non gestational diabetes mellitus(P＞0.05).The insulin resistance index increased in early,middle and late stages of gestational diabetes mellitus(P＜0.05).The insulin resistance index of gestational diabetes mellitus was higher than that of non gestational diabetes mellitus at the early,middle and late stages of pregnancy,P＜0.05.There was no difference in fasting blood glucose levels between the two groups in the early,middle and late pregnancy(P ＞ 0.05).The incidence of premature delivery, cesarean section rate,premature rupture of membranes and intrauterine distress in gestational diabetes mellitus were higher than those in non gestational diabetes mellitus,P＜0.05.The level of total bilirubin was negatively correlated with cesarean section,preterm delivery,premature rupture of membranes and intrauterine distress(P ＜ 0.05),while the level of direct bilirubin was not correlated with related pregnancy results(P ＞ 0.05).Conclusion:the examination of gestational diabetes mellitus shows that serum bilirubin level will decline,and it is negatively correlated with insulin resistance.It has certain predictive value for pregnancy outcome and is worthy of promotion.