为了寻找新的血小板活化因子抑制剂,对朝鲜药用植物进行筛选,发现侧柏(Biota orientalis)的水提取物呈现较强的抑制作用,并根据生物活性指导分离法,从侧柏的已烷提取物中分离到2种活性成分pinusolide(IC_(50)=2.5×10~(-7)M,0.0084±0.009μg/ml,n=4)和雪松醇(IC_(50)=1.3×10~(-5)M,2.9±0.79μg/ml,n=3)。此外,为寻找新的类似pinusolide结构的其它活性成 In order to search for new platelet activating factor inhibitors, the Korean medicinal plants were screened and found that the water extract of Biota orientalis showed a strong inhibitory effect, and according to the biological activity guidance separation method, the hexane from Platycladus orientalis Two active ingredients, pinusolide (IC_(50)=2.5×10~(-7)M, 0.0084±0.009μg/ml, n=4) and cedarol (IC_(50)=1.3×10~, were isolated from the extract. (-5) M, 2.9±0.79 μg/ml, n=3). In addition, in order to find new active ingredients like the pinusolide structure,