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目的探索治疗偏头痛伴有抑郁和/或焦虑患者的有效方法,研究抗抑郁/焦虑药物是否比头痛发作时单用镇痛药物疗效更佳。方法将88例伴有抑郁和/或焦虑的偏头痛患者随机分为2组,治疗组48例,用盐酸舍曲林+尼美舒利分散片(非甾体抗炎药)治疗,对照组40例,用尼美舒利分散片治疗,并进行随机单盲对照研究,同时用汉密尔顿抑郁量表评分(HAMD)和汉密尔顿焦虑量表评分(HAMA),对其抑郁和/或焦虑进行治疗前及治疗后(第4、8周)的评估。结果治疗组患者头痛发作次数显著减少(第4周P<0.05,第8周P<0.01),头痛程度显著减轻(第4周P<0.05,第8周P<0.01),头痛发作持续时间缩短(第4、8周均P<0.01);同时能显著减少HAMD(第4、8周均P<0.01)及HAMA(第4、8周均P<0.01)。结论伴有抑郁和/或焦虑的偏头痛患者,除对症治疗外,可以合并应用盐酸舍曲林。
Objective To explore an effective method to treat patients with migraine accompanied by depression and / or anxiety, and to study whether the antidepressant / anxiety drug is more effective than the single analgesic drug when the headache attacks. Methods Eighty-eight migraineurs with depression and / or anxiety were randomly divided into two groups. The treatment group (48 cases) was treated with sertraline hydrochloride and nimesulide dispersible tablets (NSAIDs), and the control group Forty patients were treated with nimesulide dispersible tablets and randomized single-blind controlled study. HAMD and HAMA were used to treat depression and / or anxiety before treatment And after treatment (weeks 4 and 8). Results The incidence of headache in treatment group decreased significantly (P <0.05 in the fourth week and P <0.01 in the eighth week), and the degree of headache was significantly reduced (P <0.05 in the fourth week and P <0.01 in the eighth week), and the duration of the headache attack was shortened (P <0.01 in the 4th and 8th week), HAMD (both P <0.01 in the 4th and 8th week) and HAMA in the 4th and 8th week (P <0.01 in the 4th and 8th week). Conclusions Migraine patients with depression and / or anxiety may be treated with sertraline hydrochloride in addition to symptomatic treatment.