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目的观察血必净注射液对经皮肾镜碎石术(PCN)后全身炎症反应综合征(SIRS)的治疗效果。方法 PCN术后并发SIRS患者58例,按随机数字表法分为常规治疗组(28例)和血必净组(30例)。常规治疗组患者给予左氧氟沙星注射液300 mg静脉滴注,2次/d;血必净组在对照组的基础上加用血必净注射液50 m L+0.9氯化钠注射液100 m L静脉滴注,2次/d。两组患者均治疗14 d。常规监测患者的心率(HR)、呼吸频率(RR)、体温(T)、白细胞计数(WBC)以及SIRS及其症状改善时间,并观察两组患者第1天和第14天血清中TNF-α、IL-6浓度变化。结果常规治疗组和血必净组的临床有效率分别为46.43%和76.67%,两组比较差异具有显著性(P<0.05)。治疗后HR、RR、T、WBC均有改善,与治疗前相比差异显著(P<0.05),但两组间各项指标差异均无显著性。血必净组HR、RR、T、WBC恢复时间明显优于常规治疗组(P<0.05)。治疗后两组患者TNF-α、IL-6均得到明显改善(P<0.05),且两组间比较有显著性差异,血必净组优于常规治疗组(P<0.05)。。结论血必净注射液能有效抑制PCN术后过激炎症反应,明显改善SIRS症状。
Objective To observe the therapeutic effect of Xuebijing injection on systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCN). Methods 58 cases of PCN complicated with SIRS were randomly divided into routine treatment group (28 cases) and Xuebijing group (30 cases). The routine treatment group was given levofloxacin 300 mg intravenous infusion, 2 times / d; Xuebijing group in the control group based on the addition of Xuebijing Injection 50 m L + 0.9 sodium chloride injection 100 m L vein Drip, 2 times / d. Two groups of patients were treated for 14 days. The heart rate (HR), respiratory rate (RR), body temperature (T), white blood cell count (WBC), SIRS and symptom improvement time of the patients were routinely monitored. , IL-6 concentration changes. Results The clinical effective rates of routine treatment group and Xuebijing group were 46.43% and 76.67%, respectively. There was significant difference between the two groups (P <0.05). After treatment, HR, RR, T, WBC improved, with significant difference (P <0.05) before treatment, but there was no significant difference between the two groups. The recovery time of HR, RR, T and WBC in Xuebijing group was significantly better than that of conventional treatment group (P <0.05). After treatment, the levels of TNF-α and IL-6 in both groups were significantly improved (P <0.05), and there was a significant difference between the two groups. Xuebijing group was better than conventional treatment group (P <0.05). . Conclusion Xuebijing injection can effectively inhibit inflammatory response after PCN and significantly improve the symptoms of SIRS.