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目的:探讨非胆汁淤积性慢性肝脏疾病患者体内维生素D的代谢状况及与甲状旁腺激素(PTH)代谢的相互关系。方法:收集非胆汁淤积性慢性肝脏疾病患者62例为研究组(包括肝硬化与非肝硬化者),26例健康体检者为对照组,分别采用ELISA法与ECLIA法检测血清25-OH-VitD3和PTH水平。结果:研究组血清25-OH-VitD3的水平低于对照组,差异有统计学意义(P<0.01)。非肝硬化组25-OH-VitD3的浓度较肝硬化组高(P<0.05)。研究组符合继发性甲旁亢患者8例(12.9%)。线性回归分析显示25-OH-VitD3浓度与总胆红素呈负相关;与白蛋白、胆碱酯酶呈正相关。结论:非胆汁淤积性慢性肝脏疾病患者中普遍存在维生素D的不足,其程度与肝功能分级相平行;血清PTH的浓度与维生素D的浓度及肝脏疾病严重程度无明显相关性。
OBJECTIVE: To investigate the metabolic status of vitamin D and its relationship with parathyroid hormone (PTH) metabolism in patients with non-cholestatic chronic liver disease. Methods: Totally 62 patients with non-cholestatic liver disease were enrolled in the study group (including cirrhosis and non-cirrhosis). Twenty-six healthy subjects were served as the control group. Serum levels of 25-OH-VitD3 And PTH levels. Results: The level of serum 25-OH-VitD3 in the study group was lower than that in the control group (P <0.01). The concentration of 25-OH-VitD3 in non-cirrhotic group was higher than that in cirrhosis group (P <0.05). The study group met the secondary hyperparathyroidism in 8 patients (12.9%). Linear regression analysis showed that the concentration of 25-OH-VitD3 was negatively correlated with total bilirubin and positively correlated with albumin and cholinesterase. Conclusion: The prevalence of vitamin D in patients with non-cholestatic chronic liver disease is low, which is parallel to the grading of liver function. There is no significant correlation between serum PTH concentration and the concentration of vitamin D and the severity of liver disease.