论文部分内容阅读
为了探讨细胞周期蛋白 E(cyclin E)在膀胱移行细胞癌的表达及其意义,采用免疫组化 S-P 法观察63例膀胱癌石蜡标本中 cyclin E 的表达情况。结果显示,膀胱癌组织中 cyclin E 的阳性表达率为39.7%,而在正常膀胱组织中 cyclin E 无阳性表达。cyclin E 阳性表达率随病理分级升高而升高,但与临床分期无关。5年随访表明,阳性表达者复发率68.0%,而阴性表达者复发率42.1%,差异有显著性意义。结论:cyclin E 表达与膀胱癌病理分级及肿瘤复发有关,与侵袭过程无关。cyclin E 表达可能是判断膀胱癌生物学行为的重要指标。
In order to investigate the expression and significance of cyclin E in transitional cell carcinoma of bladder, the expression of cyclin E in 63 cases of bladder cancer was observed by immunohistochemical S-P method. The results showed that the positive expression rate of cyclin E in bladder cancer tissues was 39.7%, while there was no positive expression of cyclin E in normal bladder tissues. The positive rate of cyclin E increased with the pathological grade, but not with the clinical stage. Five-year follow-up showed that the recurrence rate of positive expression was 68.0%, while the recurrence rate of negative expression was 42.1%, the difference was significant. Conclusion: The expression of cyclin E is related to the pathological grade of bladder cancer and tumor recurrence, but not to the invasion process. The expression of cyclin E may be an important index to judge the biological behavior of bladder cancer.