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目的分析血清B型钠尿肽(BNP)水平对于急性心力衰竭(心衰)患者病情严重程度的意义。方法 120例急性左心衰竭患者,依据严重程度(NYHA分级)分为Ⅰ~Ⅳ级,患者入院后采用电化学发光法检测血浆钠尿肽(BNP),采用心脏超声检查左室射血分数(EF)值。分析患者血清BNP水平变化与临床心衰病情严重程度之间的关系。结果患者NYHA分级为:Ⅰ级30例,血清BNP(284.51±56.93)pmol/L;Ⅱ级30例,血清BNP(589.03±60.36)pmol/L;Ⅲ级30例,血清BNP(896.35±47.01)pmol/L;Ⅳ级30例,血清BNP(2697.03±169.28)pmol/L,各级患者血清BNP水平比较差异有统计学意义(P<0.05)。血清BNP水平与EF值之间存在负相关性(r=-0.617,P<0.05)。结论血清BNP水平与急性心衰病情严重程度之间关系密切。检测血清BNP水平有助于急性心衰病情严重程度的判断。
Objective To analyze the significance of serum B-type natriuretic peptide (BNP) levels in patients with acute heart failure (CHF). Methods One hundred and twenty patients with acute left heart failure were divided into Ⅰ ~ Ⅳ grade according to the severity of NYHA class. Plasma BNP was detected by electrochemiluminescence after admission. The left ventricular ejection fraction EF) value. To analyze the relationship between the change of serum BNP level and the severity of clinical heart failure. Results NYHA class was 30 grade Ⅰ, 30 cases BNP (284.51 ± 56.93) pmol / L, 30 cases BNP (589.03 ± 60.36) pmol / L, 30 cases grade Ⅲ and 896.35 ± 47.01) (P <0.05). There were 30 cases of grade Ⅳ and BNP of 2697.03 ± 169.28 pmol / L in all grades. There was a negative correlation between serum BNP levels and EF (r = -0.617, P <0.05). Conclusion Serum BNP level is closely related to the severity of acute heart failure. Detection of serum BNP levels help determine the severity of acute heart failure.