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目的探讨冠心病不同临床表现时血管内皮细胞的激活情况。方法通过酶联免疫吸附法检测28例急性心机梗死、29例不稳定型心绞痛、25例稳定型心绞痛患者以及19例冠脉造影结果正常的对照个体的血清可溶性E选择素水平。结果急性心机梗死和不稳定型心绞痛患者的血清可溶性E选择素水平比较差异无统计学意义,分别为(62.2±6.7)ng/m l和(58.9±7.2)ng/m l,但这两组患者血清可溶性E选择素水平却较稳定型心绞痛患者(34.6±4.5)ng/m l和对照组(31.7±4.7)ng/m l明显增高,后两组个体的血清可溶性E选择素水平也相近。结论血清可溶性E选择素水平的升高反映缺血心肌发生了急性炎症反应,其是确定急性冠脉综合征患者冠状动脉粥样斑块存在不稳定性的有效指标。
Objective To investigate the activation of vascular endothelial cells in different clinical manifestations of coronary heart disease. Methods 28 cases of acute myocardial infarction, 29 cases of unstable angina pectoris, 25 cases of stable angina pectoris and 19 cases of normal control subjects with coronary angiography were measured by enzyme - linked immunosorbent assay serum soluble E - selectin levels. Results The levels of serum soluble E-selectin in patients with acute myocardial infarction and unstable angina pectoris had no significant difference (62.2 ± 6.7) ng / ml and (58.9 ± 7.2) ng / ml, respectively. However, Soluble E-selectin levels were significantly higher in patients with stable angina pectoris (34.6 ± 4.5) ng / ml and control group (31.7 ± 4.7) ng / ml, and the latter two groups were similar in serum soluble E-selectin levels. Conclusions The increase of serum soluble E-selectin level reflects the acute inflammatory reaction in ischemic myocardium, which is an effective index to determine the instability of coronary atherosclerotic plaque in patients with acute coronary syndrome.