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将妊娠大鼠随机分为5组,即敌枯双1mg/kg·d~(-1)(阳性对照组)、空白乳剂(阴性对照组)、萘实验组1000mg/kg·d~(-1)、600mg/kg·d~(-1)和60mg/kg·d~(-1),分别在怀孕第6～15d经灌胃给药。实验结果:萘为1000mg/kg·d~(-1)和600mg/kg·d~(-1)剂量组的母鼠和仔鼠均体重减轻,影响仔鼠的发育,某些骨骼发生骨化迟缓(胸骨和枕骨)。在1000mg/kg·d~(-1)组早期吸收胎和死胎发生率增加,但未发现畸形仔鼠。60mg/kg·d~(-1)组和阴性对照组经统计学处理无显著性差异,母鼠和仔鼠均无任何影响。阳性对照组则有明显的致畸作用。认为萘对大鼠不是一种致畸原。
The pregnant rats were randomly divided into 5 groups: 1mg/kg·d -1 (positive control group), blank emulsion (negative control group), and 1000mg/kg·d -1 naphthalene group. ), 600 mg/kg d-1 and 60 mg/kg d-1, were administered intragastrically on the 6th to 15th days of pregnancy. Experimental results: Mice with naphthalene at 1000 mg/kg·d -1 and 600 mg/kg·d -1 groups lost weight, affecting the development of pups and ossification of certain bones. Slow (sternal and occipital). The incidence of early absorption of fetuses and stillbirths in the 1000 mg/kg·d -1 group increased, but no deformed pups were found. There was no significant difference in statistical treatment between the 60 mg/kg·d-1 group and the negative control group, neither the mother nor the pups had any effect. The positive control group had obvious teratogenic effects. Naphthalene is not considered a teratogen in rats.