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目的:了解子痫前期患者血清和胎盘组织促肾上腺皮质激素释放激素(CRH)的变化及其意义。方法:采用ELISA测定36例子痫前期患者(子痫前期组)和39例正常孕妇(对照组)血清和胎盘血清CRH浓度组织蛋白提取液中CRH浓度,并进行组间比较。结果:子痫前期患者血清CRH浓度为(5.661±2.895 0)pmol/L,与正常妊娠时血清CRH浓度(8.753 9±2.741 0)pmol/L比较呈显著下降(P<0.001),子痫前期患者胎盘组织中CRH相对浓度为(0.314 8±0.083 65)pmol/g蛋白与正常妊娠时(0.317 8±0.110 0)pmol/g蛋白比较则没有显著性差异(P>0.05)。结论:子痫前期患者血清CRH显著降低,是子痫前期的一个重要病理生理变化,可能与疾病的的发生、发展有关。
Objective: To investigate the changes and clinical significance of corticotropin-releasing hormone (CRH) in serum and placenta of preeclampsia patients. Methods: CRH concentrations in serum and placental serum CRH concentrations in 36 cases of preeclampsia (preeclampsia group) and 39 normal pregnant women (control group) were measured by ELISA and compared between groups. Results: Serum CRH level in preeclampsia patients was (5.661 ± 2.895 0) pmol / L, which was significantly lower than that in normal pregnancy (8.753 9 ± 2.741 0) pmol / L (P <0.001) The relative concentration of CRH in the placenta of patients with (0.314 8 ± 0.083 65) pmol / g protein compared with normal pregnancy (0.317 8 ± 0.110 0 pmol / g protein) was not significantly different (P> 0.05). Conclusion: Serum CRH is significantly decreased in preeclampsia patients, which is an important pathophysiological change in preeclampsia, which may be related to the occurrence and development of the disease.