With the large-scale construction of underground gas storage in salt deposit, much more efforts have been made to assess the fatigue properties of rock salt. The fatigue damage processes the primary, steady,and accelerated phases, which is similar to the axial irrecoverable deformation compiled from the loci of the loading cycles of rock salt. The cumulative fatigue damage increases with a decrease in the loading frequency and with an increase in the stress amplitude within the range tested. To take into account the effects of loading frequency and amplitude on the fatigue behavior of rock salt subjected to cyclic loading, a low cycle fatigue damage model was exclusively established combined with the Manson–Coffin formula. The proposed damage evolution equation was validated with experimental results and proved to be efficient in the prediction of fatigue damage tendency of rock salt under different loading frequencies and amplitudes. With the large-scale construction of underground gas storage in salt deposit, much more efforts have been made to assess the fatigue properties of rock salt. Steady, and accelerated phases, which are similar to the axial irrecoverable deformation The cumulative fatigue damage increases with a decrease in the loading frequency and with an increase in the stress amplitude within the range tested. To take into account the effects of loading frequency and amplitude on the fatigue behavior of rock salt by cyclic loading, a low cycle fatigue damage model was exclusively established combined with the Manson-Coffin formula. The proposed damage evolution equation was validated with experimental results and proved to be efficient in the prediction of fatigue damage tendency of rock salt under different loading frequencies and amplitudes.