我国四位教授联合研究证明了P16基因甲基化可作为口腔黏膜上皮异型增生癌变预测标志物。该基因可在肿瘤发生前两至三年发现,可能成为尽早判断出癌前病变的一个标志物,临床灵敏度达62%、特异性为76%。据了解,人体80%的恶性肿瘤起源于上皮细胞,多数是从上皮异型增生这种癌前病变发展而来,但仅有三分之一的上皮异型增生会进展为恶性肿瘤。长期以来,医学界缺乏能够尽早区分哪些上皮异型增生病灶会癌 Four professors of our country have jointly proved that P16 gene methylation can be used as a predictive marker of carcinogenesis of dysplasia of oral mucosa. The gene can be found two to three years prior to tumorigenesis and may be a marker for early detection of precancerous lesions with a clinical sensitivity of 62% and a specificity of 76%. It is understood that 80% of human malignant tumors originated in epithelial cells, mostly from epithelial dysplasia this precancerous lesions from the development, but only one-third of epithelial dysplasia will progress to malignant tumors. For a long time, the lack of early diagnosis of epithelial dysplasia in the medical profession can be cancer