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目的比较不同治疗方法对重度阻塞性睡眠呼吸暂停综合征(OSAHS)患者生存质量中的影响。方法选取2014年12月至2015年12月符合诊断标准的重度OSAHS患者50例,将其随机分为两组,每组25例。观察组采用经鼻持续气道内正压通气(n CPAP)治疗,对照组采用UPPP治疗,比较两组治疗前后患者生存质量改善情况。结果两组ESS、SDS评分治疗后较治疗前明显降低,差异有统计学意义(P<0.05);且治疗后观察组ESS、SDS评分分别为(2.8±1.6)、(36.0±4.2)分,其降低幅度较对照组更大,差异有统计学意义(P<0.01)。治疗后观察组日常活动、症状、总分治疗后较治疗前明显改善,对照组日常活动、症状治疗后较治疗前明显改善,差异均有统计学意义(P<0.05);且治疗后观察组日常活动、情感活动、症状、总分(不含E维度)分别为(5.81±0.39)、(5.99±0.72)、(3.77±0.88)、(4.99±0.50)分,其改善幅度大于对照组,差异有统计学意义(P<0.01)。结论经鼻持续正压通气治疗OSAHS,能显著改善患者白天嗜睡程度,明显提高其生存质量,可作为治疗OSAHS的首选治疗方法临床推广应用。
Objective To compare the effects of different treatment methods on the quality of life in patients with severe obstructive sleep apnea syndrome (OSAHS). Methods Fifty patients with severe OSAHS who met the diagnostic criteria between December 2014 and December 2015 were randomly divided into two groups (n = 25 in each group). The observation group was treated with nasal continuous positive airway pressure (n CPAP), the control group was treated with UPPP, and the quality of life of the two groups was compared before and after treatment. Results The scores of ESS and SDS in both groups were significantly lower than those before treatment (P <0.05), and the scores of ESS and SDS in the observation group after treatment were (2.8 ± 1.6) and (36.0 ± 4.2) The reduction was greater than the control group, the difference was statistically significant (P <0.01). After treatment, the daily activities, symptoms and total score of observation group were significantly improved after treatment compared with those before treatment. The daily activities of the control group were significantly improved after treatment compared with those before treatment (P <0.05) (5.81 ± 0.39), (5.99 ± 0.72), (3.77 ± 0.88) and (4.99 ± 0.50) points for daily activities, affective activities, symptoms and total score, respectively. The extent of improvement was greater than that of the control group, The difference was statistically significant (P <0.01). Conclusion Nasal continuous positive pressure ventilation in the treatment of OSAHS can significantly improve the degree of daytime sleepiness and improve the quality of life of patients. It can be used as the first choice of treatment for OSAHS.