同型半胱氨酸(Hcy)是一种含硫非必需氨基酸,是甲硫氨酸代谢过程中的重要代谢产物。研究证明,母体血浆Hcy水平升高与多种不良妊娠结局相关,如自然流产、妊娠期高血压、胎盘早剥、胎儿神经管畸形及胎儿宫内发育迟缓。近年研究发现,妊娠期糖尿病孕妇也存在相对高的Hcy血症。本文现对妊娠期糖尿病患者血浆Hcy水平升高与胰岛素抵抗、脂代谢、肥胖及内皮细胞损伤的关系做一综述。 Hcy is a sulfur-containing nonessential amino acid that is an important metabolite of methionine metabolism. Studies have shown that maternal plasma Hcy levels associated with a variety of adverse pregnancy outcomes, such as spontaneous abortion, gestational hypertension, placental abruption, fetal neural tube defects and intrauterine growth retardation. Recent studies have found that pregnant women with gestational diabetes also have a relatively high Hcy blood disease. This article now in patients with gestational diabetes mellitus plasma Hcy levels and insulin resistance, lipid metabolism, obesity and endothelial cell damage is reviewed.