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目的该次实验将讨论硫辛酸对早期糖尿病足患者氧化应激与炎症反应的具体影响。方法该次实验选取了2007年1月—2016年12月在巴中市疾病预防控制中心门诊部就诊的70例糖尿病足患者为研究对象,随机分为对照组和观察组,对照组采用常规的治疗方案,观察组则在此基础上使用硫酸锌优化治疗,并观察患者氧化应激与炎症反应的具体情况。结果观察组患者在TAOC、SOD、MDA水平的对比上均优于对照组,此外,在hs-CRP、TNF-α、IL-6炎症因子的变化上均低于对照组,两组差异有统计学意义(P<0.05)。结论硫辛酸对早期糖尿病足患者氧化应激与炎症反应具有良好的缓解效用,值得在临床过程中推广应用。
Objectives This experiment will discuss the specific effects of lipoic acid on oxidative stress and inflammatory response in patients with early diabetic foot. Methods In this experiment, 70 cases of diabetic foot patients treated in outpatient department of Bazhong CDC from January 2007 to December 2016 were selected as control group and observation group. The control group was treated with routine Treatment program, the observation group is based on the use of optimal treatment of zinc sulfate, and observe the patient’s oxidative stress and inflammatory response to the specific circumstances. Results The observation group had better TAOC, SOD and MDA levels than the control group. In addition, the changes of hs-CRP, TNF-α and IL-6 in the observation group were lower than those in the control group Significance (P <0.05). Conclusion Lipoic acid has a good effect of relieving oxidative stress and inflammatory reaction in patients with early diabetic foot and is worth popularizing in clinic.