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目的:探讨A群轮状病毒性肠炎患儿血清半胱氨酸蛋白酶抑制剂C(Cystatin C,Cys-C)的变化及肾脏损害的情况。方法:对649例确诊为A群轮状病毒感染的腹泻患儿和300例正常婴幼儿进行血清Cys-C的检测,同时进行血清尿素氮和肌酐的测定。结果:观察组血清Cys-C阳性共328例,阳性率为50.5%;对照组仅有2例Cys-C阳性,观察组与对照组血清Cys-C异常的发生率差异有统计学意义(P<0.05),血清Cys-C异常程度与腹泻程度无关,与患儿性别无关;血清Cys-C异常发生率与患儿年龄有关,年龄越小越易发生Cys-C异常。结论:A群轮状病毒性肠炎可伴有肠道外感染,可引起血清Cys-C升高,造成肾脏损害。
Objective: To investigate the changes of serum cystatin C (Cys-C) and renal damage in children with rotavirus A (group A). Methods: Serum Cys-C levels were measured in 649 children with diarrhea diagnosed as group A rotavirus infection and 300 normal infants. Serum urea nitrogen and creatinine were measured simultaneously. Results: There were 328 positive cases of Cys-C in the observation group, the positive rate was 50.5%; only 2 cases of Cys-C positive in the control group, the difference of the serum Cys-C abnormalities in the observation group and the control group was statistically significant (P <0.05). The level of serum Cys-C abnormality was not related to the degree of diarrhea, but had no correlation with the sex of the children. The incidence of Cys-C abnormalities was related to the age of children. The younger the age, the more likely the occurrence of Cys-C abnormalities. Conclusion: A group of rotavirus enteritis may be associated with extraintestinal infection, can cause elevated serum Cys-C, causing kidney damage.