论文部分内容阅读
目的 以中国北方汉族群体为基础制作 2 2号染色体 6个短串联重复序列 (short tandemrepeat,STR)连锁遗传图 ,比较 2 2号染色体物理距离与遗传距离的关系。方法 用 PCR方法对 6个 STR基因座进行分型及家系分析。结果 绘制出中国北方汉族群体 2 2号染色体 6个 STR的遗传图 ,初步比较了 2 2号染色体 6个 STR基因座间遗传距离与物理距离的关系。结论 2 2号染色体上 6个 STR间的遗传距离与物理距离存在较复杂的关系 :6个 STR基因座的遗传距离不仅与物理距离的大小有关 ,而且中国人与白人以及性别之间 2 2号染色体物理距离与遗传距离的关系存在差异。
Objective To construct 6 short tandem repeats (STR) linkage maps of chromosome 2 2 on the basis of Chinese Han population in northern China and compare the relationship between physical distance and genetic distance of chromosome 2 2. Methods Six STR loci were genotyped and analyzed by PCR. Results The genetic map of 6 STRs on chromosome 2 2 of Han population of northern China was drawn, and the relationship between genetic distance and physical distance was compared between 6 STR loci on chromosome 2 and 2. Conclusion The genetic distance between 6 STRs on Chromosome 2 has a complex relationship with the physical distance: the genetic distance of the 6 STR loci is not only related to the physical distance, but also between Chinese and Caucasian and between sex 2 2 The relationship between chromosomal physical distance and genetic distance is different.