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目的:探讨急性脑梗死后患者认知功能损害与血清热休克蛋白70(HSP70)的相关性。方法:选择69例发病7日内脑梗死患者,随访3个月、6月简明精神状态量表(MMSE)、蒙特利尔认知评估量表(Mo CA)评分及血清HSP70水平。结果:1患者随访3个月、6个月MMSE、Mo CA评分与发病时明显下降,且6个月时与发病时比较差异有统计学意义(P<0.05),而HSP70水平也随时间的延长而下降,6个月与发病时比较差异有统计学意义(P<0.01);2患者血清HSP70水平和Mo CA、MMSE评分呈显著正相关(P<0.01)。结论:急性脑梗死患者认知功能损害与HSP70存在相关性,临床上可应用MMSE、Mo CA评分及血清HSP70水平判断患者认知功能损害程度。
Objective: To investigate the correlation between cognitive impairment and serum heat shock protein 70 (HSP70) in patients with acute cerebral infarction. Methods: Sixty-nine patients with cerebral infarction within 7 days after onset were followed up for 3 months and 6 months. The MMSE, MoCA score and serum HSP70 levels were measured. Results: The follow-up of 3 months, 6 months, MMSE, Mo CA score and onset decreased significantly, and 6 months after onset compared with the difference was statistically significant (P <0.05), and HSP70 levels with time (P <0.01). There was a significant positive correlation between serum HSP70 level and MoCA, MMSE score in 2 patients (P <0.01). Conclusion: There is a correlation between cognitive impairment and HSP70 in patients with acute cerebral infarction. MMSE, MoCA score and serum HSP70 level can be used to judge the extent of cognitive impairment in patients with acute cerebral infarction.