【摘 要】
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The response of cells during spreading and motility is dictated by several multi-physics events,which are triggered by extracellular cues and occur at different time-scales.For this sake,it is not completely appropriate to provide a cell with classical no
【机 构】
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Università degli Studi di Brescia,DIMI-The Mechanobiology research center at UNIBS-Brescia,25123 Bre
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The response of cells during spreading and motility is dictated by several multi-physics events,which are triggered by extracellular cues and occur at different time-scales.For this sake,it is not completely appropriate to provide a cell with classical notions of the mechanics of materials,as for “rheology” or “mechanical response”.Rather,a cell is an alive system with constituents that show a reproducible response,as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network,but that reorganize in response to external cues in a non-exactly-predictable and reproducible way.Aware of such complexity,in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility,accounting for the relocation of proteins on advecting lipid membranes.
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