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依照抗心律失常作用进行分类颇为适用,但有很大局限性,因为某一药物及其代谢产物有多种作用,Ⅰ类作用药物是抑制内向快速除极钠流从而延缓动作电位(0相)上升速率的局部麻醉剂。再按抑制钠通道的强度,以及药物对于动作电位、传导速率及复极的作用,进一步分为 IA、IB 及 IC 亚类。Ⅲ类作用药物延长复极及不应期。因抗心律失常药物作用广泛,所以安全有效的治疗要求熟悉所给予的每种药物的药理学特性,并仔细评估病人的现状及病史。联合用药,例如 IA 类和 IB类合用,延缓传导的作用增强,延长不应期,而副作用最小。
Classification according to the role of anti-arrhythmic quite applicable, but a lot of limitations, because of a drug and its metabolites have a variety of role, Ⅰ class of drugs is to inhibit the inward rapid depolarization of sodium and thus slow down the action potential (0 phase ) Rising rate of local anesthetic. Then by the inhibition of sodium channel intensity, and the action of drugs on the action potential, conduction velocity and repolarization, further divided into IA, IB and IC subclasses. Class Ⅲ drugs to extend repolarization and refractory period. Because antiarrhythmic drugs are widely used, safe and effective treatment requires familiarity with the pharmacological properties of each drug given, and careful assessment of the patient’s status and medical history. Combination therapy, such as the combination of IA and IB, enhances the delayed conduction and prolongs the refractory period with minimal side effects.