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本实验首次证明人工塑造小肠梗阻家兔动脉血中血管活性肠肽(VIP)高于梗阻前7.9倍,十二指肠组织 VIP 增加1倍。十二指肠灌注大承气汤后,血浆 VIP 含量下降50%,对照组升高65%。门脉血 VIP 含量为动脉血的4倍,其改变趋势与动脉血相似。VIP 增高是肠梗阻时导致肠壁充血、水肿及肠腔渗液增加等病理改变的重要因素之一,大承气汤对其有治疗作用,该方剂对生理和病理状态下的 VIP 水平表现为双向调节作用。
This experiment demonstrated for the first time that the arterial blood in the artificially created small intestine obstruction was higher than 7.9 times the vasoactive intestinal peptide (VIP) in the arterial blood before obstruction, and the duodenum tissue VIP increased by 1 time. After infusion of Dachengqi Decoction in the duodenum, plasma VIP levels decreased by 50%, and the control group increased by 65%. Portal blood VIP content is 4 times that of arterial blood, and its changing trend is similar to that of arterial blood. Increased VIP is one of the important factors that cause intestinal pathological changes such as congestion, edema, and increased intestine effusion during intestinal obstruction. Dachengqi Decoction has a therapeutic effect on it, and this formula shows VIP levels under physiological and pathological conditions. Bidirectional regulation.