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目的分析B超与肝纤维化指标联合监测对血吸虫病肝纤维化的诊断效果及其应用价值。方法对2007-2012年收治的615例血吸虫病患者进行诊断,将金标准病理诊断为肝纤维化的患者作为病例组,其余患者为对照组,分别对两组患者进行B超、肝纤维化四项指标的检测分析。结果肝纤维化Ⅱ、Ⅲ级患者的肝纤维化指标Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(IV-C)、层粘连蛋白(LN)、透明质酸(HA)的值均高于对照组,差异有统计学意义;肝纤维化I级患者与对照组肝纤维化指标PC-Ⅲ、IV-C、LN、HA的值相比无统计学差异;肝纤维化指标和B超联合检查肝纤维化敏感度为98.53%、特异度为98.27%、符合率为98.69%。结论 B超与肝纤维化指标联合监测血吸虫病肝纤维化具有良好的诊断价值。
Objective To analyze the diagnostic value and its application value of combined monitoring of B-ultrasound and liver fibrosis markers on liver fibrosis of schistosomiasis. Methods A total of 615 schistosomiasis patients were enrolled in this study from 2007 to 2012. The patients with liver fibrosis diagnosed by gold standard pathology were selected as the case group and the rest patients as the control group. Item index test analysis. Results The values of type Ⅲ procollagen (PC-Ⅲ), type Ⅳ collagen (IV-C), laminin (LN) and hyaluronic acid (HA) In the control group, the difference was statistically significant. There was no significant difference in the levels of PC-Ⅲ, IV-C, LN, and HA among the patients with grade I liver fibrosis and those in the control group. The indexes of liver fibrosis and B- The joint examination of liver fibrosis sensitivity was 98.53%, specificity was 98.27%, the coincidence rate was 98.69%. Conclusion B-ultrasound and liver fibrosis indicators combined with monitoring of liver fibrosis schistosomiasis has a good diagnostic value.