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本文讨论炎症性肠病时(IBD)血循和肠道中淋巴细胞和巨噬细胞激活的证据;检查白介素(IL)1和2所起作用,以及特异性受体拮抗剂治疗效应。 T细胞激活与IL-2活化的T细胞所产生的IL-2通过激活T细胞、B细胞和巨噬细胞产生多种细胞因子,而这些细胞因子在各种急、慢性炎症性疾病,包括IBD中可能起重要作用。 在Crohn病(CD)血循淋巴细胞上早期激活抗原(T_9)的表达增高,这与CD活动指数(CDAI)的临床活动度积分呈相关性。在活动性混合IBD和活动性CD表达αIL-2 r的血循
This article discusses evidence of blood circulation and activation of lymphocytes and macrophages in the intestinal tract during inflammatory bowel disease (IBD); examines the role of interleukin (IL) 1 and 2 and the therapeutic effects of specific receptor antagonists. IL-2 produced by T-cell activation and IL-2-activated T cells produces a variety of cytokines by activating T cells, B cells and macrophages, and these cytokines produce a variety of acute and chronic inflammatory diseases including IBD May play an important role. The increased expression of early activation antigen (T_9) on Crohn’s disease (CD) hematopoietic lymphocytes correlates with the score of clinical activity of the CD activity index (CDAI). Blood circulation of αIL-2 r was expressed in both active mixed IBD and active CD