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从加拿大引进纯系BB种鼠,对自发性遗传性糖尿病BB鼠模型慢性肾脏病变进行定量研究,并观察代谢控制对其的影响。与对照鼠比较,糖尿病鼠肾小球内基底膜样物质的体积分数明显增高;毛细血管基底膜明显增厚,与血糖呈明显正相关。提示糖尿病慢性肾脏病变与代谢紊乱有密切关系。
The introduction of purebred BB rats from Canada quantitative study of chronic kidney disease in spontaneous genetic diabetic BB rat model and observe the impact of metabolic control on them. Compared with the control mice, the volume fraction of basilar membrane-like substances in glomeruli in diabetic rats was significantly increased; the capillary basement membrane was significantly thicker and positively correlated with blood glucose. Tip diabetic chronic kidney disease and metabolic disorders are closely related.