铂嘧啶兰是一类具有抗癌作用的寡聚铂络合物。Aggarwal等曾发现它们可用做电镜标本特异的染色剂,区分细胞是否有致瘤性。但由于影响结果的因素很多,不同作者所得结果并不一致。我们根据对二氯二水铂与尿嘧啶反应动力学的研究结果,制备了反应时间较短、聚合度较低、水溶性较大的铂尿嘧啶兰(以下简称铂兰),并用它对癌细胞与正常细胞进行电子染色处理,发现铂兰与细胞表面的结合,随固定步骤与染液配方的不同而有三种 Platinum pyrimidine blue is a class of anti-cancer effects of oligomeric platinum complexes. Aggarwal et al. Have found that they can be used as electron microscopy-specific stain to distinguish whether the cells have tumorigenicity. However, due to the many factors that affect the results, the results obtained by different authors are not consistent. Based on the results of the reaction kinetics of dichlorodihydroplatinum and uracil, we prepared platinum-uracil-blue (hereinafter referred to as “platinum-blue”) with shorter reaction time, lower degree of polymerization and larger water solubility, Cells and normal cells were electronically stained and found that the combination of platinum and cell surface, with the fixed step and the dye formulation of the three different