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目的:研究海水浸泡疗法对服用索拉非尼后并发严重手足皮肤反应患者的疗效。方法:服用索拉非尼后出现严重的相关性手足皮肤反应(II度和III度)病人,每天早晚用海水浸泡2次,与未用海水浸泡的索拉非尼药物相关性手足反应患者进行对比。结果:对症治疗组水疱平均愈合时间为(11.7±7.6)天,而海水浸泡治疗组的平均愈合时间为(2.5±0.5)天,多数病人在应用海水浸泡后第2天疼痛明显改善。结论:海水浸泡可改善严重的索拉非尼药物相关性手足皮肤反应。
Objective: To study the effect of seawater immersion therapy on patients with severe hand-foot skin reaction after taking sorafenib. METHODS: Patients with severely associated hand, foot and skin reactions (Grade II and III) after sorafenib treatment were soaked in seawater twice daily, sooner or later, with sorafenib-free hand-foot-and-arm patients who had not soaked in seawater Compared. Results: The average healing time of blisters in symptomatic treatment group was (11.7 ± 7.6) days, while the average healing time in seawater immersion treatment group was (2.5 ± 0.5) days. In most patients, the pain was significantly improved on the second day after immersion in seawater. CONCLUSIONS: Seawater immersion improves severe sorafenib drug-related hand-foot skin reactions.