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目的观察前列地尔联合奥曲肽治疗急性胰腺炎的临床疗效。方法急性胰腺炎患者63例,随机分为2组,治疗组32例给予奥曲肽0.3mg+生理盐水60mL持续泵入(25～50μg/h)(7～14d)及前列地尔10μg+生理盐水250mL静脉滴注,1次/d(7～14d);对照组31例仅给予奥曲肽0.3mg+生理盐水60mL持续泵入(25～50μg/h)(7～14d)。结果治疗组在腹痛缓解时间、上腹压痛消失时间、肠鸣音恢复时间、血淀粉酶恢复时间均短于对照组(P<0.05),总有效率优于对照组(P<0.05)。结论前列地尔联合奥曲肽治疗急性胰腺炎安全有效。
Objective To observe the clinical efficacy of alprostin combined with prostaglandin in the treatment of acute pancreatitis. Methods A total of 63 patients with acute pancreatitis were randomly divided into 2 groups. In the treatment group, 32 patients were given intravenous infusion of octreotide 0.3mg + saline 60mL (25 ~ 50μg / h) (7 ~ 14d) and alprostadil 10μg + saline 250mL (7 ~ 14d). In the control group, 31 patients were given only 0.1mg octreotide 0.3mg + normal saline 60mL (25 ~ 50μg / h) for 7 ~ 14d. Results The treatment group had shorter response time to abdominal pain, disappearance of abdominal tenderness, recovery time of bowel sounds and recovery time of serum amylase (P <0.05), and the total effective rate was better than that of the control group (P <0.05). Conclusions Alprostadil is a safe and effective treatment of acute pancreatitis.