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目的探讨淋巴组织细胞性淋巴瘤的组织学特点及免疫组化特征。方法收集９例淋巴组织细胞性淋巴瘤进行组织学观察，并行免疫组化染色。结果组织学上淋巴结正常结构消失，完全为肿瘤细胞所代替，瘤细胞８例为小淋巴细胞性，１例为大细胞性。组织细胞或连成一片，或单个散在于淋巴组织中，组织细胞有异型性，偶见分裂象。在免疫组化上瘤细胞呈ＵＣＨＬ１＋，组织细胞呈Ｍａｃ３８７＋（或单个散在，或粘连成片）。１例大细胞性瘤细胞呈ＢｅｒＨ２＋，其余８例均为ＢｅｒＨ２－。Ｌ２６全部为阴性。结论淋巴组织细胞性淋巴瘤是外周Ｔ细胞淋巴瘤中一种较为特殊的组织学类型。
Objective To investigate the histological features and immunohistochemical features of lymphoid tissue cell lymphoma. Methods 9 cases of lymphoid histiocytic lymphoma were collected for histological observation and immunohistochemical staining. Results The normal structure of lymph nodes disappeared histologically and completely replaced by tumor cells. The tumor cells were small lymphocytic in 8 cases and large cell in 1 case. The cells of the tissue are connected to one another, or scattered in the lymphoid tissue. The cells of the tissue have atypicality, and occasional schizoids appear. On immunohistochemistry, the tumor cells were UCHL1+ and the histiocytes were Mac387+ (either scattered individually or adherently). One case of large cell tumor was BerH2+, and the rest 8 were BerH2-. L26 is all negative. Conclusion Lymphoid cell lymphoma is a special histological type in peripheral T-cell lymphoma.