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口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是一种慢性、隐匿性、具有癌变倾向的炎性疾病。患者进食刺激性食物时口内疼痛,口腔黏膜苍白僵硬,触摸有条索感,舌运动、张口受限,以致咀嚼、吞咽困难,有的甚至发生癌变,严重影响患者的生存质量和身心健康。复杂的发病机制导致该病至今尚无满意的治疗方法。本文介绍了目前主要的治疗方法,包括药物治疗、物理治疗和手术治疗等,主张根据病变发展的阶段,采用多种方法联合治疗。
Oral submucous fibrosis (OSF) is a chronic, occult, inflammatory disease with a cancerous tendency. Patients with irritating mouth when eating oral pain, pale and stiff oral mucosa, touching a cable sense, tongue movement, limited mouth opening, resulting in chewing, swallowing difficulties, and some even have cancer, seriously affecting the patient’s quality of life and physical and mental health. Complex pathogenesis has led to the disease so far no satisfactory treatment. This article describes the current main treatment methods, including drug treatment, physical therapy and surgical treatment, advocating the stage of development of the disease, the use of a variety of methods combined treatment.