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目的:采用Meta分析方法评价丹红注射液辅助西医常规治疗急性脑梗死的有效性、安全性。方法:计算机检索Cochrane Library,Pub Med、Embase、Sino Med、中国知网、维普期刊数据库和万方数据库有关丹红注射液治疗急性脑梗死的随机对照临床试验文献,检索时限为各数据库建库至2016年8月。提取资料通过Stata 13.1软件进行Meta分析。结果:共纳入57个随机对照试验,累计5 474例患者。Meta分析结果显示,丹红注射液辅助西医常规可提高临床总有效率(RR=1.62,95%CI:1.46~1.79,P<0.01),提高患者日常生活活动能力(MD=9.61,95%CI:4.80~14.42,P<0.01),改善神经功能缺损(MD=-4.34,95%CI:-5.13~-3.54,P<0.01),改善血液流变学指标。有17篇文献明确无不良反应,3篇研究报道了共12例不良反应,其他文献均未对安全性做出说明。结论:丹红注射液辅助西医常规治疗急性脑梗死具有较好的疗效和安全性,值得临床推广。
OBJECTIVE: To evaluate the effectiveness and safety of Danhong injection in the treatment of acute cerebral infarction by western medicine by Meta analysis. Methods: A randomized controlled clinical trial of Danhong injection for the treatment of acute cerebral infarction was searched by computer, and the search period was from the database to the databases of Cochrane Library, Pub Med, Embase, Sino Med, CNKI, VIP Library and Wanfang Database August 2016. Meta-analysis was performed using Stata 13.1 software. Results: A total of 57 randomized controlled trials were enrolled and a total of 5 474 patients were enrolled. The results of Meta analysis showed that Danhong injection could improve the total effective rate (RR = 1.62, 95% CI: 1.46-1.79, P <0.01) and improve the activities of daily living in patients (MD = 9.61, 95% CI : 4.80 ~ 14.42, P <0.01), improve the neurological deficit (MD = -4.34,95% CI: -5.13 ~ -3.54, P <0.01) and improve the indexes of hemorheology. There are 17 articles clearly no adverse reactions, 3 studies reported a total of 12 cases of adverse reactions, no other literature to explain the safety. CONCLUSION: Danhong injection has the good curative effect and safety in assisting western medicine routine treatment of acute cerebral infarction, which is worthy of clinical promotion.