血凝素样氧化低密度脂蛋白受体-1(LOX-1)是内皮细胞摄取氧化低密度脂蛋白(ox-LDL)的特异性受体。高脂血症、氧化应激等多种因素可以促进LOX-1的表达。LOX-1表达通过诱导各种黏附分子和炎症因子的表达、激活蛋白激酶、诱导细胞凋亡等途径促进平滑肌细胞和巨噬细胞吞噬脂质,并转化为泡沫细胞,促进动脉粥样硬化斑块的形成。 The hemagglutinin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a specific receptor for the uptake of oxidized low density lipoprotein (ox-LDL) by endothelial cells. Hyperlipidemia, oxidative stress and other factors can promote LOX-1 expression. LOX-1 expression promotes phagocytosis of lipocytes in smooth muscle cells and macrophages by inducing the expression of various adhesion molecules and inflammatory factors, activating protein kinases and inducing cell apoptosis, and transforming them into foam cells to promote atherosclerotic plaque Formation.