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目的分析不同剂量阿托伐他汀对冠脉粥样硬化斑块的有效性与药理作用。方法将医院收治的90例冠脉粥样硬化斑块患者随机分为观察组和对照组,每组45例。观察组采用大剂量阿托伐他汀治疗,对照组采用常规剂量阿托伐他汀治疗。观察2组患者的随访结果、临床治疗效果、hs-CRP与血脂水平变化。结果观察组治疗总有效率为91.11%,高于对照组的35.56%(P<0.01);治疗后观察组hs-CRP、血脂水平均优于对照组,差异有统计学意义(P<0.05)。结论对于冠脉粥样硬化斑块患者而言,大剂量阿托伐他汀可有效延缓病情进展,值得临床。
Objective To analyze the efficacy and pharmacological effects of different doses of atorvastatin on coronary atherosclerotic plaques. Methods Ninety patients with coronary atherosclerotic plaque admitted to the hospital were randomly divided into observation group and control group, with 45 cases in each group. The observation group was treated with high-dose atorvastatin, and the control group was treated with conventional dose of atorvastatin. The follow-up results, clinical treatment effect, hs-CRP and blood lipid levels in two groups were observed. Results The total effective rate of observation group was 91.11%, which was higher than that of control group (35.56%, P <0.01). After treatment, hs-CRP and blood lipid level in observation group were better than those in control group (P <0.05) . Conclusion For patients with coronary atherosclerotic plaque, high-dose atorvastatin can effectively delay the progression of the disease and is worth clinical.