自然流产是最常见的妊娠并发症,发病率为8%~30%~([1])。自然流产也是不孕症的高危因素,其病因复杂,60%与遗传、子宫解剖学异常等因素有关,但有40%的自然流产仍难以解释~([2])。社会工业化发展使环境污染日益严重~([3]),其中重金属及持久性有机污染物(persistent organic pollutants,POPs)是最常见的持久性污染物,通过食物、水等途径暴露 Spontaneous abortion is the most common complication of pregnancy, the incidence rate of 8% to 30% ~ ([1]). Spontaneous abortion is also a risk factor for infertility, its etiology is complex, 60% and genetic, uterine anatomy and other factors, but 40% of spontaneous abortion is still difficult to explain ~ ([2]). The industrialization of society has led to the worsening of environmental pollution ([3]). Among them, heavy metals and persistent organic pollutants (POPs) are the most common persistent pollutants exposed through food and water