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目的了解云南省当地各民族孕妇唐氏综合征高风险状况,探讨孕中期唐氏征筛查检测的临床意义。并提出干预措施,为制定预防出生缺陷措施提供决策依据。方法收集云南省第一人民医院对云南省德宏州人民医院2010年-2013年产检5000例孕15~20+6周妊娠妇女进行唐氏征筛查的资料,并对其结果进行分析。结果 5000例孕妇中,唐氏综合征筛查高风险115例,占筛查总数的2.3%。唐氏征筛查阳性病例行羊水穿刺术,发现21-三体综合征15例,占筛查病例的0.3%;18-三体综合征18例,占筛查总数的0.36%;神经管缺损高风险13例,占筛查总数的0.26%。结论有效的孕中期产前筛查能够在一定程度上减少新生儿缺陷的发生率。
Objective To understand the prevalence of Down’s syndrome in pregnant women of various ethnic groups in Yunnan province and to explore the clinical significance of Down’s syndrome screening in the second trimester of pregnancy. And put forward intervention measures to provide decision-making basis for the formulation of measures to prevent birth defects. Methods The First People’s Hospital of Yunnan Province collected data of Down’s syndrome screening from 5000 pregnant women of 15-20 + 6 weeks of gestation in Dehong People’s Hospital of Yunnan Province from 2010 to 2013 and analyzed the results. Results Of the 5000 pregnant women, Down’s syndrome was screened for a high risk of 115 cases, accounting for 2.3% of the total number of screening. Down’s syndrome screening positive cases of amniocentesis and found that 21 cases of trisomy 15 cases, accounting for 0.3% of screening cases; 18 cases of trisomy 18, accounting for 0.36% of the total number of screening; neural tube defects High risk in 13 cases, accounting for 0.26% of the total number of screening. Conclusion The effective prenatal screening in the second trimester can reduce the incidence of neonatal defects to a certain extent.