目的:观察丹红注射液联合叶酸治疗脑梗死的疗效及其对S100β、同型半胱氨酸(Hcy)和高敏C反应蛋白(hs-CRP)的影响。方法:选择脑梗死患者400例,随机分为观察组和对照组,每组各200例,对照组予以叶酸治疗,观察组在对照组的基础上予以丹红注射液治疗。观察两组治疗后的疗效,及其治疗前后血清S100β、Hcy和hs-CRP水平的变化。结果:观察组的总有效率为95.50%,明显优于对照组的75.50%,差异有统计学意义(χ2=17.258,P<0.05)。治疗后两组的NIHSS评分、S100β、Hcy和hsCRP水平较治疗前明显降低(P<0.01),观察组较对照组下降更为明显(P<0.01)。ADL评分较治疗前明显升高(P<0.01),观察组的作用更为明显(P<0.01)。结论:丹红注射液联合叶酸治疗能够提高对脑梗死患者的疗效,改善预后,其机理可能与降低机体的Hcy、S100β和hs-CRP水平具有密切关系。 Objective: To observe the therapeutic effect of Danhong injection and folic acid on cerebral infarction and its effect on S100β, homocysteine ​​(Hcy) and high sensitive C-reactive protein (hs-CRP). Methods: 400 patients with cerebral infarction were randomly divided into observation group and control group, with 200 cases in each group. The control group was treated with folic acid. The observation group was given Danhong injection on the basis of the control group. The therapeutic effects of the two groups were observed, and the changes of serum S100β, Hcy and hs-CRP before and after treatment were observed. Results: The total effective rate in the observation group was 95.50%, which was significantly better than that in the control group (75.50%, χ2 = 17.258, P <0.05). After treatment, NIHSS score, S100β, Hcy and hsCRP levels in both groups were significantly lower than those before treatment (P <0.01), and the observation group was more obvious than the control group (P <0.01). ADL score was significantly higher than before treatment (P <0.01), the role of the observation group was more obvious (P <0.01). Conclusion: Danhong injection combined with folic acid can improve the curative effect and improve the prognosis of patients with cerebral infarction. The mechanism may be related to the reduction of Hcy, S100β and hs-CRP.