论文部分内容阅读
目的探讨丙戊酸钠治疗对癫痫患儿血浆神经肽Y、血糖及体重指数的影响。方法采用放免法检测癫痫患儿服用丙戊酸钠治疗前后血浆神经肽Y水平及治疗前后血糖、体重指数变化。结果丙戊酸钠治疗4个月后,46例癫痫患儿服药后神经肽Y平均浓度较服药前明显增加(P<0.05),血糖水平明显高于治疗前(P<0.01),体重指数明显高于治疗前(P<0.01)。结论癫痫患儿服用丙戊酸钠治疗引起血糖升高、体重指数增加可能与血浆神经肽Y浓度升高有关。
Objective To investigate the effects of sodium valproate on plasma neuropeptide Y, blood glucose and body mass index in children with epilepsy. Methods Radioimmunoassay was used to detect plasma neuropeptide Y levels before and after treatment with epirubicin in children with epilepsy and the changes of blood glucose and body mass index before and after treatment. Results After the treatment of sodium valproate for 4 months, the average neuropeptide Y concentration in 46 epileptic children was significantly higher than that before treatment (P <0.05), the blood glucose level was significantly higher than before treatment (P <0.01), and the body mass index was significantly higher Higher than before treatment (P <0.01). Conclusion Epilepsy children taking sodium valproate treatment may cause hyperglycemia, the increase of body mass index may be related to the increase of plasma neuropeptide Y concentration.