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目的比较清音丸由蜜丸改为片剂后对免疫低下模型小鼠作用的变化。方法取ICR小鼠,随机分成9组:空白对照组,模型对照组,参芪颗粒,清音丸和片大、中、小剂量组(按生药量计,0.910g/kg,0.455g/kg,0.228g/kg),连续给药14d,观察比较清音丸、清音片对腹腔注射环磷酰胺所致免疫低下模型小鼠网状内皮系统单核巨噬细胞的吞噬功能以及对鸡红细胞所致小鼠特异性抗体的生成有无明显促进作用;二硝基氯苯致小鼠迟发型超敏反应试验,连续给药12d后观察小鼠T淋巴细胞转化为致敏淋巴细胞反应情况。结果清音丸、清音片具有增强小鼠网状内皮系统吞噬功能及增强体液免疫功能的作用。两种剂型药效对细胞免疫无明显差异,但从数值上看清音片略优于清音丸。结论清音丸由蜜丸剂型改为片剂后对非特异性免疫和体液免疫都有增强作用。
Objective To compare the effects of Qiyin Pills from Miwan to tablets on the immunosuppressive model mice. Methods ICR mice were randomly divided into 9 groups: blank control group, model control group, Shenqi Granule, Qingyin Pills and large, medium and small dose groups (0.910g / kg, 0.455g / kg, 0.228 g / kg) for 14 days. The effects of Qingyin Pill and Qingyin Pill on the phagocytic function of reticuloendothelial system monocyte-macrophage in immunocompromised mice induced by cyclophosphamide, Specific antibody production had no significant role in promoting; dinitrochlorobenzene-induced delayed type hypersensitivity test in mice, 12 days after continuous administration of mouse T lymphocytes transformed into sensitized lymphocyte reaction. The results of voiceless pill, voiceless tablets have enhanced reticuloendothelial system phagocytosis and enhance the role of humoral immune function. Two kinds of formulations of the efficacy of cellular immunity was no significant difference, but slightly better than the value of clear voice pill pills. Conclusions The voiceless pill changed from pill form to tablet, which enhanced the nonspecific immunity and humoral immunity.